Exercise induced renal dysfunction demonstrated both in hypertensives and normotensive controls studies by Tc-99m-DTPA
It was previously reported that the hippurate transport disturbance after exercise is a specific phenomenon to patients with hypertension. The authors' study with Tc-99m-DTPA revealed exercise induced renal dysfunction not only in hypertensives (H) but also in normotensive controls (N). The details of the investigation is presented. Tc-99m-DTPA was intravenously injected at rest and during bicycle ergometric stress to 14 H and 14 N in sitting position. Serial dynamic renal images were taken, of which data were simultaneously stored in a data processor for later analysis. The renogram was drawn setting ROI on each kidney. Peak counts (PC) of vascular phase, peak time (PT) of secretory phase and radioisotope retention rate (RR) at 10 minutes were the parameters being compared between at rest and at exercise. GFR of each kidney was determined. Blood samples were obtained at rest and at the end of exercise for the measurement of aldosterone (ALD), plasma renin activity (PRA) and catecholamines (A, NA). Exercise caused significant lowering of PC, prolongation of PT and increase in RR (10 min. counts/peak counts) both in H and N. GFR (miota/min.) during exercise was significantly lower than at rest in both H (80 +- 22 vs 93.8 +- 16.9, p<0.02) and N (84 +- 17 vs 102 +- 15, p<0.01). ALD, PRA, A and NA are all elevated during exercise both in H and N. None of the rest-exercise differences significantly differed between H and N. The data indicate the exercise induced renal dysfunction demonstrated by Tc-99m-DTPA renograms is not specified to H but can also be observed in N, which may be resulted from the common changes in H and N of GFR and humoral factors.
- Research Organization:
- Toho Univ. Sch. of Med., Tokyo
- OSTI ID:
- 7031024
- Report Number(s):
- CONF-850611-; TRN: 87-010757
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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HYPERTENSION
DIAGNOSIS
KIDNEYS
RADIOISOTOPE SCANNING
RENOGRAPHY
ALDOSTERONE
BIOLOGICAL STRESS
BLOOD PLASMA
CATECHOLAMINES
DATA ACQUISITION SYSTEMS
DIAGNOSTIC USES
EXERCISE
IMAGE PROCESSING
MONITORING
PATIENTS
TECHNETIUM 99
TRACER TECHNIQUES
ADRENAL HORMONES
ALDEHYDES
AMINES
AROMATICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOMEDICAL RADIOGRAPHY
BLOOD
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CORTICOSTEROIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
HORMONES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
MATERIALS
MEDICINE
MINERALOCORTICOIDS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PREGNANES
PROCESSING
RADIOISOTOPES
RADIOLOGY
STEROID HORMONES
STEROIDS
SYMPTOMS
TECHNETIUM ISOTOPES
USES
VASCULAR DISEASES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550602 - Medicine- External Radiation in Diagnostics- (1980-)