Cloning of two novel ABC transporters mapping on human chromosome 9

Journal Article · Sun May 01 00:00:00 EDT 1994 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1994.1237· OSTI ID:7029746

Luciani, M F; Savary, S; Chimini, G ^[1]; Denizot, F ^[2]; Mattei, M G ^[3]

---

1. Centre d'Immunologie, Marseille (France)
2. Centre de Sequencage, Marseille (France)
3. Centre de Genetique Medicale, Marseille (France)

The family of ATP binding cassette (ABC) transporters or traffic ATPases is composed of several membrane-associated proteins that transport a great variety of solutes across cellular membranes. Two novel mammalian members of the family, ABC1 and ABC2, have been identified by a PCR-based approach. They belong to a group of traffic ATPases encoded as a single multifunctional protein, such as CFTR, STE 6, and P-glycoproteins. Their peculiar structural features and close relationship to ABC transporters involved in nodulation suggest that ABC1 and ABC2 define a novel subgroup of mammalian traffic ATPases. 51 refs., 7 figs.

• OSTI ID: 7029746
• Journal Information: Genomics; (United States), Vol. 21:1; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HUMAN CHROMOSOME 9
GENETIC MAPPING
PORINS
GENES
DNA-CLONING
POLYMERASE CHAIN REACTION
BIOTECHNOLOGY
CHROMOSOMES
CLONING
DNA HYBRIDIZATION
GENE AMPLIFICATION
GENETIC ENGINEERING
HUMAN CHROMOSOMES
HYBRIDIZATION
MAPPING
MEMBRANE PROTEINS
NUCLEIC ACID HYBRIDIZATION
ORGANIC COMPOUNDS
PROTEINS
550400* - Genetics