Chemotherapy response as a prognosticator for survival in patients with limited squamous cell lung cancer treated with combined chemotherapy and radiotherapy
Twenty-two patients with limited unresectable squamous cell lung cancer were treated with 6 courses of combination chemotherapy consisting of cyclophosphamide, adriamycin, cisplatin, and bleomycin (CAP-Bleo) and short-course thoracic irradiation started after the first 4 weeks of chemotherapy. Of 20 patients with visible tumor who were treated with 4 weeks of chemotherapy alone, 10 (50%) had a tumor regression in that 4 week period and 10 did not. Those patients with tumor regression had significantly better progression free and overall survivals than did patients with no chemotherapy regressions (medians of 258 days vs. 136 days and 356 days vs. 150 days respectively). The original bleomycin dose had to be reduced by 50% primarily because of excessive radiation esophagitis that has not been reported with use of either the CAP regimen or bleomycin along in conjunction with thoracic irradiation. An initial chemotherapy regression seems to be a good prognosticator for progression-free and overall survival in patients with limited squamous cell lung cancer treated with combined chemotherapy and radiotherapy.
- Research Organization:
- Mayo Clinic, Rochester, NY
- OSTI ID:
- 7029379
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 6:7
- Country of Publication:
- United States
- Language:
- English
Similar Records
Comparison of survival in patients with non-oat cell carcinoma of lung using various types of treatment modalities
Randomized trial of radiotherapy to the thorax in limited small-cell carcinoma of the lung treated with multiagent chemotherapy and elective brain irradiation: a preliminary report
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD COUNT
BIOLOGICAL RADIATION EFFECTS
CARCINOMAS
CHEMOTHERAPY
RADIOSENSITIVITY EFFECTS
ESOPHAGUS
LUNGS
BLEOMYCIN
CHEST
DOXORUBICIN
ENDOXAN
INFLAMMATION
LEUKOPENIA
LINEAR ACCELERATORS
MEV RANGE 01-10
PATIENTS
RADIATION DOSES
RADIOINDUCTION
SIDE EFFECTS
ACCELERATORS
ALKYLATING AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
DIGESTIVE SYSTEM
DISEASES
DOSES
DRUGS
ENERGY RANGE
HEMIC DISEASES
MEV RANGE
NEOPLASMS
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RESPIRATORY SYSTEM
SYMPTOMS
THERAPY
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)