Effects of inhaled alpha-emitting actin-ides on mouse alveolar macrophages

Journal Article · Wed Jul 01 00:00:00 EDT 1992 · Environmental Health Perspectives; (United States)

DOI:https://doi.org/10.1289/ehp.9297177· OSTI ID:7027426

Morgan, A; Talbot, R J ^[1]

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1. AEA Environment and Energy, Oxfordshire (United Kingdom)

The effects of inhaled alpha-emitting actinides on the alveolar macrophage (AM) population of the rodent lung are reviewed and, in particular, of the effects of [sup 239]PuO[sub 2] on murine AM. The effects discussed include changes that AM pool size, macrophage diameter, mobility, phagocytic competence, and enzyme content. Finally, similarities in the dose-response relationships for the induction of nuclear aberrations by alpha emitters and in the induction of lung tumors by the same materials are noted. 14 refs., 9 figs.

• OSTI ID: 7027426
• Journal Information: Environmental Health Perspectives; (United States), Vol. 97; ISSN 0091-6765
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
ACTINIDES
DOSE-RESPONSE RELATIONSHIPS
MACROPHAGES
PHAGOCYTOSIS
ULTRASTRUCTURAL CHANGES
BIOLOGICAL RADIATION EFFECTS
LUNGS
MICE
PLUTONIUM 239
PLUTONIUM OXIDES
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
CONNECTIVE TISSUE CELLS
ELEMENTS
EVEN-ODD NUCLEI
HEAVY NUCLEI
ISOTOPES
MAMMALS
METALS
MORPHOLOGICAL CHANGES
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PHAGOCYTES
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
RADIATION EFFECTS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
SPONTANEOUS FISSION RADIOISOTOPES
TRANSURANIUM COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560150* - Radiation Effects on Animals
550200 - Biochemistry
550300 - Cytology