Brain damage in a new hemorrhagic shock model in the rat using long-term recovery

Journal Article · Thu Mar 01 00:00:00 EST 1990 · Journal of Cerebral Blood Flow and Metabolism; (USA)

DOI:https://doi.org/10.1038/jcbfm.1990.36· OSTI ID:7025937

Yamauchi, Y; Kato, H; Kogure, K ^[1]

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1. Tohoku Univ. School of Medicine, Sendai (Japan)

A new shock model in the rat using hemorrhagic hypotension for production of brain damage is described. Hemorrhagic shock was induced by lowering arterial blood pressure with bleeding. The MABP was maintained at approximately 25 mm Hg, accompanied by isoelectric EEG, and then shed blood was retransfused. At 1 week of recovery, morphological and 45Ca autoradiographic changes were examined. No brain damage was observed in rats after 1 min of isoelectric EEG. Mild neuronal damage in the hippocampal CA1 subfield was seen in some animals after 2 min of isoelectric EEG. Severe and consistent neuronal loss in the hippocampal CA1 subfield was recognized after 3 min of isoelectric EEG. Additional damage was also seen in the dentate hilus and the thalamus in some animals. This model can be used to study the pathophysiology of postshock brain damage and to assess new therapies following shock.

• OSTI ID: 7025937
• Journal Information: Journal of Cerebral Blood Flow and Metabolism; (USA), Vol. 10:2; ISSN 0271-678X
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BRAIN
HEMORRHAGE
NERVOUS SYSTEM DISEASES
PATHOGENESIS
AUTORADIOGRAPHY
BIOLOGICAL RECOVERY
BLOOD PRESSURE
CALCIUM 45
ELECTROENCEPHALOGRAPHY
HYPOTENSION
RATS
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CALCIUM ISOTOPES
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
NERVOUS SYSTEM
NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPES
RECOVERY
RODENTS
SYMPTOMS
VERTEBRATES
550901* - Pathology- Tracer Techniques