Augmentation of macrophage growth-stimulating activity of lipids by their peroxidation

Journal Article · Thu Feb 15 00:00:00 EST 1990 · Journal of Immunology; (USA)

OSTI ID:7025524

Yui, S; Yamazaki, M ^[1]

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1. Teikyo Univ., Kanagawa (Japan)

Previously, we reported that some kinds of lipids (cholesterol esters, triglycerides, and some negatively charged phospholipids) that are constituents of lipoproteins or cell membranes induce growth of peripheral macrophages in vitro. In this paper, we examined the effect of peroxidation of lipids on their macrophage growth-stimulating activity because lipid peroxidation is observed in many pathological states such as inflammation. When phosphatidylserine, one of the phospholipids with growth-stimulating activity, was peroxidized by UV irradiation, its macrophage growth-stimulating activity was augmented in proportion to the extent of its peroxidation. The activity of phosphatidylethanolamine was also increased by UV irradiation. On the other hand, phosphatidylcholine or highly unsaturated free fatty acids, such as arachidonic acid and eicosapentaenoic acid, did not induce macrophage growth irrespective of whether they were peroxidized. The augmented activity of UV-irradiated phosphatidylserine was not affected by the coexistence of an antioxidant, vitamin E or BHT. These results suggest that some phospholipids included in damaged cells or denatured lipoproteins which are scavenged by macrophages in vivo may induce growth of peripheral macrophages more effectively when they are peroxidized by local pathological processes.

• OSTI ID: 7025524
• Journal Information: Journal of Immunology; (USA), Vol. 144:4; ISSN 0022-1767
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MACROPHAGES
CELL DIVISION
PHOSPHOLIPIDS
CHEMICAL RADIATION EFFECTS
CATTLE
IN VITRO
MICE
ULTRAVIOLET RADIATION
VITAMIN E
ANIMAL CELLS
ANIMALS
CHEMISTRY
CONNECTIVE TISSUE CELLS
DOMESTIC ANIMALS
ELECTROMAGNETIC RADIATION
ESTERS
LIPIDS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PHAGOCYTES
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RODENTS
RUMINANTS
SOMATIC CELLS
VERTEBRATES
VITAMINS
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture