Decreased lung function and exposure to diisocyanates (HDI and HDI-BT) in car repair painters: Observations on re-examination 6 years after initial study
- Karolinska Hospital, Stockholm (Sweden)
Thirty-six car painters and 115 control persons participated in a follow-up investigation 6 years after the initial study, including measurement of lung function (dynamic spirometry and nitrogen washout test) and estimation of exposure to diisocyanates based on individual working routines, use of respiratory protection equipment, and measurements. The mean exposure for the car painters was 0.0015 mg/m3 hexamethylenediisocyanate (HDI) and 0.09 mg/m3 hexamethylenediisocyanate-biurettrimer (HDI-BT), but frequently there were peak exposures exceeding 2.0 mg/m3 HDI-BT for at least 30 sec. Compared with smoking controls, the smoking car painters had greater yearly reduction in FVC (95 versus 38 ml), FEV1 (61 versus 28 ml), and VC (77 versus 30 ml). The nonsmoking car painters showed no differences in lung volumes compared with their nonsmoking controls. The impairment correlated well with the frequency of high peak exposures to HDI-BT, but not with the mean exposure to diisocyanates.
- OSTI ID:
- 7024901
- Journal Information:
- American Journal of Industrial Medicine; (USA), Vol. 17:3; ISSN 0271-3586
- Country of Publication:
- United States
- Language:
- English
Similar Records
Design and evaluation of a solid sampler for the monitoring of airborne 1,6-hexamethylene diisocyanate (HDI) and its prepolymers in two-component spray painting
Five-year longitudinal study of workers employed in a new toluene diisocyanate manufacturing plant
Related Subjects
CYANATES
HEALTH HAZARDS
AIR POLLUTION
LUNGS
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
PAINTS
SWEDEN
TOBACCO SMOKES
AEROSOLS
BODY
CARBONIC ACID DERIVATIVES
COATINGS
COLLOIDS
DISPERSIONS
EUROPE
HAZARDS
NITROGEN COMPOUNDS
ORGANIC COMPOUNDS
ORGANS
POLLUTION
RESIDUES
RESPIRATORY SYSTEM
SCANDINAVIA
SMOKES
SOLS
WESTERN EUROPE
560300* - Chemicals Metabolism & Toxicology