Effect of acute and chronic ethanol on the agonist responses of vascular smooth muscle
The authors studied the effects of ETOH on the response of isolated rat thoracic aorta rings to phenylephrine (PE) and angiotensin II (AII). They also examined the effect of chronic ETOH on vascular reactivity to PE and ETOH in vitro for up to 18 weeks during the development of ETOH-induced hypertension. The dose-responses (DR) of both PE and AII were shifted to the right by ETOH in a dose dependent manner. All was more sensitive to this shift which was significantly different from the controls at 50 mM ETOH compared to 150 mM ETOH for PE. The combination of 1 nM saralasin and 150 mM ETOH depressed the AII DR more than saralasin alone but was comparable to that of ETOH. The combination of 150 mM ETOH and 0.3 nM prazosin depressed the PE DR less than prazosin alone but more than ETOH alone. The effect of .01 nM verapamil on the PE DR was similar to that of saralasin on the AII DR. The results of the chronic study showed that the PE DR of the aortic rings from ETOH rats was comparable to that of control rats until the 18th week when it was shifted to the right. The PE DR was shifted rightward by 150 mM ETOH to the same extent in both control and ETOH rats which suggests that ETOH has ..cap alpha..-receptor blocking properties. Vascular reactivity to PE and to ETOH remained the same throughout the ETOH drinking period indicating a lack of development of hypersensitivity to PE or tolerance to ETOH which may contribute to the hypertensive effect of ETOH.
- Research Organization:
- E. Carolina Univ. School of Medicine, Greenville, NC
- OSTI ID:
- 7024608
- Report Number(s):
- CONF-8604222-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:4; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ETHANOL
BIOLOGICAL EFFECTS
HYPERTENSION
PATHOGENESIS
ACUTE EXPOSURE
ANTIHYPERTENSIVE AGENTS
CHRONIC EXPOSURE
DOSE-RESPONSE RELATIONSHIPS
MUSCLES
RATS
SYNERGISM
ALCOHOLS
ANIMALS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
DISEASES
DRUGS
HYDROXY COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
RODENTS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology