Studies on regional cerebral pH in patients with cerebral tumors using continuous inhalation of /sup 11/CO/sub 2/ and positron emission tomography
Regional cerebral pH (rpH) was measured in 12 patients with cerebral tumours and in 5 normal subjects using continuous inhalation of /sup 11/CO/sub 2/ and positron emission tomography (PET). Cerebral tumours with a disrupted blood-brain barrier (BBB) on computed tomography scanning had a similar rpH to that of equivalent regions of contralateral brain tissue (mean tumour rpH, 6.98; mean contralateral brain pH, 6.99). Cerebral tumours with an intact BBB were consistently found to be more alkaline than contralateral brain tissue (mean tumour rpH, 7.09). There was no significant difference between the mean rpH values obtained for peripheral cortical gray and central white matter in normal subjects (7.02 and 6.98, respectively). It is concluded that in spite of reports of raised levels of aerobic glycolysis in neoplastic tissue, there is no evidence that cerebral tumour rpH values are depressed.
- Research Organization:
- Hammersmith Hospital, London, England
- OSTI ID:
- 7024134
- Journal Information:
- J. Cereb. Blood Flow Metab.; (United States), Vol. 5
- Country of Publication:
- United States
- Language:
- English
Similar Records
Measurement of regional cerebral pH in human subjects using continuous inhalation of /sup 11/CO/sub 2/ and positron emission tomography
Error analysis for the determination of cerebral blood flow with the continuous inhalation of 15O-labeled carbon dioxide and positron emission tomography
Related Subjects
BRAIN
PH VALUE
POSITRON COMPUTED TOMOGRAPHY
CARBON 11
DIAGNOSTIC USES
NEOPLASMS
BLOOD-BRAIN BARRIER
CARBON DIOXIDE
GLYCOLYSIS
INHALATION
PATIENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON COMPOUNDS
CARBON ISOTOPES
CARBON OXIDES
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
INTAKE
ISOTOPES
LIGHT NUCLEI
METABOLISM
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIOISOTOPES
TOMOGRAPHY
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics