Transient engraftment of syngeneic bone marrow after conditioning with high-dose cyclophosphamide and thoracoabdominal irradiation in a patient with aplastic anemia

Journal Article · Mon Jan 01 00:00:00 EST 1990 · American Journal of Hematology; (USA)

DOI:https://doi.org/10.1002/ajh.2830330111· OSTI ID:7018631

Matsue, K; Niki, T; Shiobara, S; Ueda, M; Ohtake, S; Mori, T; Matsuda, T; Harada, M ^[1]

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1. Kanazawa Univ. Hospital (Japan)

We describe the clinical course of a 16 year old girl with aplastic anemia who was treated by syngeneic bone marrow transplantation. Engraftment was not obtained by simple infusion of bone marrow without immunosuppression. The patient received a high-dose cyclophosphamide and thoracoabdominal irradiation, followed by second marrow transplantation from the same donor. Incomplete but significant hematologic recovery was observed; however, marrow failure recurred 5 months after transplantation. Since donor and recipient pairs were genotypically identical, graft failure could not be attributed to immunological reactivity of recipient cells to donor non-HLA antigens. This case report implies that graft failure in some cases of aplastic anemia might be mediated by inhibitory cells resistant to cyclophosphamide and irradiation.

• OSTI ID: 7018631
• Journal Information: American Journal of Hematology; (USA), Vol. 33:1; ISSN 0361-8609
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANEMIAS
COMBINED THERAPY
BONE MARROW
TRANSPLANTS
ABDOMEN
ANTINEOPLASTIC DRUGS
SURVIVAL TIME
ANIMAL TISSUES
BODY
BODY AREAS
DISEASES
DRUGS
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
ORGANS
SYMPTOMS
THERAPY
TISSUES
550603* - Medicine- External Radiation in Therapy- (1980-)
550600 - Medicine