Induction of marrow hypoxia by radioprotective agents
Many compounds that possess sulfhydryl groups have been shown to protect bone marrow from radiation injury. The most effective thiol radioprotective agent is ethiofos (S-2-(3-aminopropylamino)ethylphosphorothoic acid or WR-2721). The ability of thiol and non-thiol radioprotectors to induce hypoxia was determined using binding of ({sup 3}H)misonidazole by bone marrow cells as a measure of hypoxia. When administered at maximally radioprotective doses, four drugs (WR-2721, cysteamine, 5-hydroxytryptamine, and 16,16-dimethyl prostaglandin E2) significantly increased the amount of ({sup 3}H)misonidazole bound by marrow cells, while no significant increase in binding was observed with three other agents (endotoxin, AET, superoxide dimutase). Doses of WR-2721 previously shown to provide suboptimal radioprotection did not significantly increase {sup 3}H-misonidazole binding. These results suggest that the physiological effects of some radioprotectors, that is, their ability to induce marrow hypoxia, may contribute to their efficacy in vivo.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
- OSTI ID:
- 7018562
- Report Number(s):
- AD-A-214330/3/XAB; AFRRI-SR-89-26
- Resource Relation:
- Other Information: Pub. in Radiation Research, Vol. 118, 581-586(1989)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BONE MARROW
RADIATION PROTECTION
BONE MARROW CELLS
CHEMICAL BONDS
MISONIDAZOLE
RADIOPROTECTIVE SUBSTANCES
EVALUATION
TRITIUM
TRACER TECHNIQUES
ANOXIA
DRUGS
ENDOTOXINS
IN VIVO
RADIATION INJURIES
THIOLS
ANIMAL CELLS
ANIMAL TISSUES
ANTIGENS
ANTINEOPLASTIC DRUGS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CONNECTIVE TISSUE CELLS
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROGEN ISOTOPES
IMIDAZOLES
INJURIES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIOISOTOPES
RADIOSENSITIZERS
SOMATIC CELLS
TISSUES
TOXIC MATERIALS
TOXINS
YEARS LIVING RADIOISOTOPES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture