PBF/BNCT Program for cancer treatment

Technical Report · Fri Sep 01 00:00:00 EDT 1989

DOI:https://doi.org/10.2172/7018387· OSTI ID:7018387

Ackermann, A. L. ^[1]; Dorn, III., R. V.

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1. ed.

Highlights of the PBF/BNCT Program during August included: gross boron analysis in tissue, blood, and urine (biological samples for boron analysis were received from WSU, including samples from five p-BPA/melanoma dogs and seven BSH plasmapheresis dogs); analytical methodologies development for BSH (borocaptate sodium) purity determination (much effort this month focussed on the effort to develop a procedure for the separation of the optical isomeric forms of p-BPA for future application in melanoma BNCT); boron microscopic analytical development (analysis of SIMS images of boron-treated U-87 cells is complete and results will show cellular concentrations of B, K, Na, and Ca under different drug dosages); noninvasive boron quantification determination (optimization of pulse sequences for {sup 10}BSH MRI may result from the dissolving of double quantum coherence differences between {sup 10}BSH and {sup 11}BSH); and additional measurements have greatly narrowed the previously observed differences between calculated and measured total radiation doses in phantoms.

• Research Organization: EG and G Idaho, Inc., Idaho Falls, ID (United States)
• Sponsoring Organization: DOE/NE
• DOE Contract Number: AC07-76ID01570
• OSTI ID: 7018387
• Report Number(s): EGG-BNCT-8353-Vol.3-No.9; ON: DE90007044
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BRAIN
NEUTRON THERAPY
NEUTRON CAPTURE THERAPY
DOSIMETRY
ACCELERATORS
BLOOD
COMPILED DATA
DOGS
NEOPLASMS
NEUTRON FLUENCE
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MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANS
RADIOLOGY
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560152* - Radiation Effects on Animals- Animals
560151 - Radiation Effects on Animals- Man