High frequency of benign mediastinal uptake of gallium-67 after completion of chemotherapy in children with high-grade non-Hodgkin's lymphoma
- National Cancer Institute, Bethesda, MD (USA)
We observed increased gallium-67 uptake in the mediastinum after completion of chemotherapy in 10 of 62 patients with non-Hodgkin's lymphoma. All 10 were under 15 years of age, yielding a frequency of 43% in this age group. The interval between cessation of chemotherapy and the development of increased gallium-67 uptake ranged from 1 to 8 months, and the abnormality persisted for 2 to 59 months. Serial chest x-rays were performed in all patients, and four of the 10 had transient widening of the mediastinum that remained within normal limits for the children's ages. Three patients had chest computed tomographic (CT) scans at the time of increased gallium-67 uptake, and one of the three had serial scans that showed a mediastinal mass consistent with thymic enlargement. All of the patients were asymptomatic and none were biopsied. All 10 remained well, with a mean follow-up of 52.5 months. The phenomenon we describe is probably due to rebound thymic hyperplasia, which is a benign and transient condition. We conclude that abnormal mediastinal gallium-67 uptake after completion of chemotherapy is likely to be benign and transient if the patients are young, have small non-cleaved-cell histology, are without other evidence of lymphoma recurrence, and do not have initial mediastinal involvement. Progressive widening of the mediastinum on chest x-ray is cause for suspicion and requires further evaluation. Serum lactate dehydrogenase (LDH) levels may not be helpful in differentiating a benign from a malignant process.
- OSTI ID:
- 7018371
- Journal Information:
- Journal of Clinical Oncology; (USA), Vol. 7:12; ISSN 0732-183X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Comparison of Ga-67 planar imaging and single photon emission computed tomography in malignant chest disease
MACOP-B and Involved-Field Radiotherapy Is an Effective and Safe Therapy for Primary Mediastinal Large B Cell Lymphoma
Related Subjects
GALLIUM 67
UPTAKE
LYMPHOMAS
COMBINED THERAPY
MEDIASTINUM
RADIONUCLIDE KINETICS
ADOLESCENTS
BIOMEDICAL RADIOGRAPHY
CHILDREN
EMISSION COMPUTED TOMOGRAPHY
LACTATE DEHYDROGENASE
PATIENTS
THYMUS
X RADIATION
AGE GROUPS
BETA DECAY RADIOISOTOPES
BODY
BODY AREAS
CHEST
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
GALLIUM ISOTOPES
HEMIACETAL DEHYDROGENASES
IMMUNE SYSTEM DISEASES
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
ISOTOPES
LYMPHATIC SYSTEM
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXIDOREDUCTASES
RADIATIONS
RADIOISOTOPES
RADIOLOGY
THERAPY
TOMOGRAPHY
560161* - Radionuclide Effects
Kinetics
& Toxicology- Man