Regulation of serotonin release from enterochromaffin cells of rat cecum mucosa
- INSERM U6-CNRS, URA 142, Marseille (France)
The release of endogenous serotonin or previously taken up tritiated serotonin from isolated strips of rat cecum mucosa containing enterochromaffin cells was studied in vitro. Release of tritiated serotonin was increased by potassium depolarization and was decreased by tetrodotoxin, veratridine and the absence of calcium. Endogenous serotonin was released at a lower rate than tritiated serotonin; endogenous serotonin release was stimulated by potassium depolarization but was unaffected by tetrodotoxin, veratridine or the absence of calcium. Carbachol, norepinephrine, clonidine and isoproterenol decreased release of tritiated serotonin but had less or reverse effect on release of endogenous serotonin. The results suggest two different serotoninergic pools within the enterochromaffin cell population.
- OSTI ID:
- 7016442
- Journal Information:
- Journal of Pharmacology and Experimental Therapeutics; (USA), Vol. 253:2; ISSN 0022-3565
- Country of Publication:
- United States
- Language:
- English
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BIOCHEMICAL REACTION KINETICS
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LARGE INTESTINE
MUCOUS MEMBRANES
RATS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ALKALI METALS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
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DIGESTIVE SYSTEM
DRUGS
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GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
INTESTINES
ISOTOPE APPLICATIONS
KINETICS
MAMMALS
MEMBRANES
METALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
RODENTS
SYMPATHOMIMETICS
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550201* - Biochemistry- Tracer Techniques