Synthesis and identification of the monocation Tc(CPI) sub 6 sup + in Tc(CNC(CH sub 3 ) sub 2 COOCH sub 3 ) sub 6 Cl and its hydrolysis products. [Tc(CNC(CH sub 3 ) sub 2 COOCH sub 3 ) sub 6 Cl and monocation Tc(CPI) sub 6 sup +]
- Massachusetts Inst. of Tech., Cambridge (United States)
- Harvard Medical School and Brigham and Women's Hospital, Boston, MA (United States)
The complex Tc(CNC(CH{sub 3}){sub 2}COOCH{sub 3}){sub 6}Cl (cation designated as Tc(CPI){sub 6}{sup +}) is one of a series of isonitrile-coordinated technetium complexes being investigated as a prototype radiopharmaceutical to evaluate myocardial perfusion. It has been prepared from the pertechnetate ion by aqueous Na{sub 2}S{sub 2}O{sub 4} reduction in the presence of the functionalized isocyanide ligand. The octahedral compound with its relatively reactive ester substituents is stable under aqueous aerobic conditions within the pH range 5-7. At high pH, however, the ester moieties undergo random, base-catalyzed hydrolysis while the six ligands remain coordinated in a fixed geometry to the central metal. The nine predicted carboxylic acid containing species were separated and identified by RP-HPLC, FAB-MS, IR, and {sup 99}Tc NMR methods. Specific k' values obtained from the RP-HPLC of these characterized compounds were used to identify technetium containing metabolites of the radiopharmaceutical. Varying rates of in vitro enzymatic hydrolysis at the terminal ester moieties of the coordinated ligands were shown to occur when this compound was incubated with blood serum from different animal species.
- OSTI ID:
- 7014050
- Journal Information:
- Inorganic Chemistry; (United States), Vol. 30:22; ISSN 0020-1669
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
HYDROLYSIS
IN VITRO
INFRARED SPECTRA
LIQUID COLUMN CHROMATOGRAPHY
MASS SPECTRA
MYOCARDIUM
NMR SPECTRA
PERTECHNETATES
PH VALUE
QUALITATIVE CHEMICAL ANALYSIS
STRUCTURAL CHEMICAL ANALYSIS
TECHNETIUM 99
TECHNETIUM COMPLEXES
THIN-LAYER CHROMATOGRAPHY
TISSUE DISTRIBUTION
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
CHEMICAL ANALYSIS
CHEMICAL REACTIONS
CHROMATOGRAPHY
COMPLEXES
DECOMPOSITION
DISTRIBUTION
DRUGS
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LYSIS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
RADIOISOTOPES
REFRACTORY METAL COMPOUNDS
SEPARATION PROCESSES
SOLVOLYSIS
SPECTRA
SYNTHESIS
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENT COMPOUNDS
YEARS LIVING RADIOI
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400201 - Chemical & Physicochemical Properties