Altered host resistance to Listeria monocytogenes in mice exposed to 1-chloroacetophenone (CN) vapours

Journal Article · Mon Jun 01 00:00:00 EDT 1992 · Biomedical and Environmental Sciences; (United States)

OSTI ID:7013404

Kumar, P; Kumar, P; Zachariah, K; Rai, G P; Vijayraghavan, R ^[1]

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1. Defence Research and Development Establishment, Gwalior (India)

Short term repeated exposure of 1-chloroacetophenone (CN) vapours at a concentration of 0.153 mg per litre for 15 minutes daily on 10 consecutive days in Swiss albino male mice resulted in increased mortality to Listeria monocytogenes. Significantly elevated bacterial growth was observed in the spleen and liver of the CN exposed animals. The increased bacterial count in these organs was evident within 4-6 days post challenge as compared to vehicle exposed infected and unexposed infected animals. Increased susceptibility to infection has been considered to be the function of immune alteration due to cumulative short term effects of CN vapour inhalation. This may be attributed to immunotoxic effects of CN on T-cells mediated macrophage functions.

• OSTI ID: 7013404
• Journal Information: Biomedical and Environmental Sciences; (United States), Vol. 5:2; ISSN 0895-3988
• Country of Publication: United States
• Language: English

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ORGANIC CHLORINE COMPOUNDS
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RETICULOENDOTHELIAL SYSTEM
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GLANDS
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