Ethanol-induced increase in portal blood glow: Role of adenosine

Journal Article · Fri Apr 01 00:00:00 EST 1988 · American Journal of Physiology; (USA)

OSTI ID:7011358

Orrego, H; Carmichael, F J; Saldivia, V; Giles, H G; Sandrin, S; Israel, Y ^[1]

---

1. Univ. of Toronto, Ontario (Canada)

The mechanism by which ethanol induces an increase in portal vein blood flow was studied in rats using radiolabeled microspheres. Ethanol by gavage resulted in an increase of 50-70% in portal vein blood flow. The ethanol-induced increase in portal blood flow was suppressed by the adenosine receptor blocker 8-phenyltheophylline. By itself, 8-phenyltheophylline was without effect on cardiac output or portal blood flow. Adenosine infusion resulted in a dose-dependent increase in portal blood flow. This adenosine-induced increase in portal blood flow was inhibited by 8-phenyltheophylline in a dose-dependent manner. Both alcohol and adenosine significantly reduced preportal vascular resistance by 40% and 60%, respectively. These effects were fully suppressed by 8-phenyltheophylline. It is concluded that adenosine is a likely candidate to mediate the ethanol-induced increase in portal vein blood flow. It is suggested that an increase in circulating acetate and liver hypoxia may mediate the effects of alcohol by increasing tissue and interstitial adenosine levels.

• OSTI ID: 7011358
• Journal Information: American Journal of Physiology; (USA), Vol. 254:4; ISSN 0002-9513
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
ADENOSINE
DOSE-RESPONSE RELATIONSHIPS
BLOOD FLOW
RADIOASSAY
ETHANOL
BIOLOGICAL EFFECTS
THEOPHYLLINE
BIOCHEMISTRY
COBALT 57
LIVER
MICROSPHERES
PORTAL SYSTEM
RATS
SCANDIUM 46
VEINS
ALCOHOLS
ANIMALS
AROMATICS
AZAARENES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CHEMISTRY
COBALT ISOTOPES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PURINES
RADIOISOTOPES
RIBOSIDES
RODENTS
SCANDIUM ISOTOPES
SECONDS LIVING RADIOISO
VASODILATORS
VERTEBRATES
XANTHINES
560300* - Chemicals Metabolism & Toxicology
551001 - Physiological Systems- Tracer Techniques