Several mRNAs with variable 3[prime] untranslated regions and different stability encode the human PR264/SC35 splicing factor
- Institut Curie, Orsay (France)
The authors have recently established that several mRNAs encode the PR264/SC35 splicing factor and that their expression is related to that of c-Myb in human hematopoietic cells. They now report that the various PR264 mRNAs whose expression is transactivated by c-Myb proteins encode an identical PR264/SC35 polypeptide. These mRNAs differ only in their 3[prime] untranslated sequences and exhibit significantly different half-lives. They also show that there is a direct correlation between the length of the 3[prime] untranslated region and the stability of the mRNA species. Given that 5[prime] and 3[prime] splice site selection mediated by the PR264/SC35 splicing factor is concentration-dependent, the authors postulate that alternative splicing of the 3[prime] untranslated sequences might represent another key element in regulating the levels of PR264/SC35 expression during hematopoietic differentiation.
- OSTI ID:
- 7009631
- Journal Information:
- Proceedings of the National Academy of Sciences of the United States of America; (United States), Vol. 91:3; ISSN 0027-8424
- Country of Publication:
- United States
- Language:
- English
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