Nuclear medicine progress report for quarter ending December 31, 1983
In this report a multi-step synthesis of 19-iodo-3-(R,S)-methyl-18-nonadecenoic acid is described. In this new agent, the iodine is stabilized as a trans vinyliodide and the methyl group in position-3 was introduced to inhibit ..beta..-oxidation. The /sup 125/I-labeled agent was evaluated in unfasted rats and showed essentially no loss from the myocardium over the initial 30 min period. Three new (/sup 125/I)-labeled iodopentenyl-substituted cation analogues have also been prepared and evaluated in rats to determine the relation between structure and relative heart and hepatobiliary uptake. The triphenylarsonium and dihexylphenylphosphonium analogues showed tissue distribution properties very similar to the parent -triphenylphosphonium agent. The -dimethyl-n-octylphosphonium analogue, however, showed lower heart uptake and much greater hepatobiliary clearance. Carrier-free /sup 103/ /sup 106/RuCl/sub 3/ by utilizing ruthenocenylmethyltrimethylammonium iodide as the key synthetic intermediate. The amino acid analog was evaluated as a pancreatic imaging agent but no selective uptake in the pancreas was observed. The High Flux Isotope Reactor (HFIR) resumed operation in January after replacement of the beryllium reflector shield. For the July-December 1983 period, several shipments of radiolabeled agents were made to Medical Cooperative investigators. 9 references, 3 figures, 4 tables.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 7007714
- Report Number(s):
- ORNL/TM-9037; ON: DE84012037
- Country of Publication:
- United States
- Language:
- English
Similar Records
Design, synthesis, and evaluation of omega-iodovinyl- and omega-iodoalkyl-substituted methyl-branched long-chain fatty acids
Nuclear medicine progress report for quarter ending December 31, 1985
Related Subjects
NUCLEAR MEDICINE
RESEARCH PROGRAMS
ALANINES
CARBOXYLIC ACIDS
IODINE 125
LABELLED COMPOUNDS
ORNL
RADIOPHARMACEUTICALS
RUTHENIUM 103
RUTHENIUM 106
SYNTHESIS
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MEDICINE
NATIONAL ORGANIZATIONS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOISOTOPES
RUTHENIUM ISOTOPES
US AEC
US DOE
US ERDA
US ORGANIZATIONS
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics