Cerebral blood flow in the newborn infant: comparison of Doppler ultrasound and /sup 133/xenon clearance
Two techniques of Doppler ultrasound examination, continuous-wave and range-gated, applied to the anterior cerebral artery and to the internal carotid artery, were compared with /sup 133/xenon clearance after intravenous injection. Thirty-two sets of measurements were obtained in 16 newborn infants. The pulsatility index, the mean flow velocity, and the end-diastolic flow velocity were read from the Doppler recordings. Mean cerebral blood flow was estimated from the /sup 133/Xe clearance curves. The correlation coefficients between the Doppler and the /sup 133/Xe measurements ranged from 0.41 to 0.82. In the subset of 16 first measurements in each infant, there were no statistically significant differences between the correlation coefficients of the various Doppler ultrasound variables, but the correlation coefficients were consistently lower for the pulsatility index than for mean flow velocity or end-diastolic flow velocity, and they were consistently higher for the range-gated than for the continuous-wave Doppler technique.
- Research Organization:
- Department of Neonatology, Rigshospitalet, Copenhagen, Denmark
- OSTI ID:
- 7007445
- Journal Information:
- J. Pediatr.; (United States), Vol. 104:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BRAIN
BLOOD FLOW
RADIOISOTOPE SCANNING
ULTRASONOGRAPHY
ARTERIES
BLOOD-PLASMA CLEARANCE
NEONATES
XENON 133
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CLEARANCE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
XENON ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics