Studies on the antimutagenic activities of garlic extract

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Environmental and Molecular Mutagenesis; (USA)

DOI:https://doi.org/10.1002/em.2850130413· OSTI ID:7007000

Knasmueller, S ^[1]; Szakmary, A ^[2]; Domjan, G ^[3]; de Martin, R ^[4]

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1. Univ. of Innsbruck (Austria)
2. Austrian Research Center Seibersdorf (Austria)
3. State Sanatory Sopron (Hungary)
4. Sandoz Research Institute, Basle (Switzerland)

Experiments with Salmonella tester strains indicated that aqueous garlic extract possesses antimutagenic properties toward ionizing radiation, peroxides, adriamycin, and N-methyl-N{prime}-nitro-nitrosoguanidine. The assumption that radical scavenging garlic constituents, i.e., molecules with sulfur moieties, might be responsible for the inhibitory effect of aqueous extract toward mutagenesis induced by radiation and radiomimetic compounds was confirmed by the results of subsequent experiments; (1) garlic extract attenuated the lethal effects of {gamma}-rays on repair-deficient E. coli strains; (2) the garlic constituent allicin (thio-2-propene-1-sulfinic acid S-allyl ester) is partly responsible for the reduced radiation-induced mutagenesis in Salmonella typhimurium TA 102. No such inhibitory effects were detected with alliin (S-allyl-L-cysteine sulfoxide) or cysteine; (3) aqueous garlic extract inhibited hydrogen-peroxide-induced lipid peroxidation. Results obtained in preliminary experiments with Chinese hamster ovary cells suggest that the antimutagenic properties of garlic extract are not restricted to procaryotic cells.

• OSTI ID: 7007000
• Journal Information: Environmental and Molecular Mutagenesis; (USA), Vol. 13:4; ISSN 0893-6692
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BIOLOGICAL RADIATION EFFECTS
CHO CELLS
DNA REPAIR
MOLECULAR BIOLOGY
SPICES
EXTRACTION
ANTINEOPLASTIC DRUGS
COBALT 60
DOXORUBICIN
ESCHERICHIA COLI
GAMMA RADIATION
HERBS
LIPIDS
NITROSO COMPOUNDS
OXIDATION
PEROXIDES
REVERTANTS
SALMONELLA TYPHIMURIUM
ANIMAL CELLS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHEMICAL REACTIONS
COBALT ISOTOPES
DRUGS
ELECTROMAGNETIC RADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
MUTANTS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN COMPOUNDS
PLANTS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RECOVERY
REPAIR
SALMONELLA
SEPARATION PROCESSES
YEARS LIVING RADIOISOT
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture