Addition of molecular methods to mutation studies with Drosophila melanogaster
- Louisiana State Univ., Baton Rouge, LA (USA)
For 80 years, Drosophila melanogaster has been used as a major tool in analyzing Mendelian genetics. By using chromosome inversions that suppress crossing over, geneticists have developed a large number of stocks for mutation analysis. These stocks permit numerous tests for specific locus mutations, lethals at multiple loci on any chromosome, chromosome exchanges, insertions, and deletions. The entire genome can be manipulated for a degree of genetic control not found in other germ-line systems. Recombinant DNA techniques now permit analysis of mutations to the nucleotide level. By combining classical genetic analysis with recombinant DNA techniques, it is possible to analyze mutations that range from chromosome aberrations and multilocus deficiencies to single nucleotide transitions.
- DOE Contract Number:
- FG05-86ER60393
- OSTI ID:
- 7006975
- Journal Information:
- Environmental and Molecular Mutagenesis; (USA), Vol. 14:16; ISSN 0893-6692
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHROMOSOMAL ABERRATIONS
RADIOINDUCTION
DROSOPHILA
GENETICS
GENE RECOMBINATION
MOLECULAR BIOLOGY
DNA BASE TRANSITIONS
LETHAL MUTATIONS
NITROSOUREAS
NUCLEOTIDES
X RADIATION
ANIMALS
ARTHROPODS
BIOLOGY
DIPTERA
ELECTROMAGNETIC RADIATION
FLIES
FRUIT FLIES
INSECTS
INVERTEBRATES
IONIZING RADIATIONS
MUTATIONS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATIONS
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture