Effects of copper supplementation on erythrocyte superoxide dismutase activity levels in rheumatoid arthritis patients

Journal Article · Thu Feb 09 00:00:00 EST 1989 · FASEB Journal (Federation of American Societies for Experimental Biology); (USA)

OSTI ID:7005652

Marten, J T; DiSilvestro, R A ^[1]

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1. Purdue Univ. West Lafayette, IN (USA)

Rheumatoid arthritis (RA) patients are reported to possess lower than normal levels of Cu-Zn superoxide dismutase (SOD) activity. The contribution of copper status to these low values has not been examined. To address this issue, blood samples were obtained from 10 RA patients before and after 28 days of daily oral copper supplementation (2 mg/day). All patients were receiving gold therapy. Each RA subject, before supplementation, displayed lower erythrocyte SOD values than any of 25 age matched controls. The mean value for the RA subjects was about 40% lower than the control mean, whether expressed as units per ml packed cells or per mg hemoglobin. Erythrocyte SOD activity levels were increased in all subjects by the 4 week copper supplementation, with 7 of the patients showing at least a 22% increase. Presupplement SOD activities showed no correlation with serum C-reactive protein contents, an indicator of acute phase response. Serum levels of the copper containing acute phase protein ceruloplasmin, showed variable responses to copper supplementation. The studies described here are currently being extended to include RA subjects not being treated with gold and to include supplemented controls.

• OSTI ID: 7005652
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (USA), Vol. 3:3; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
COPPER
BIOLOGICAL EFFECTS
SUPEROXIDE DISMUTASE
BIOCHEMICAL REACTION KINETICS
BLOOD
DIET
ENZYME ACTIVITY
ERYTHROCYTES
NUTRITIONAL DEFICIENCY
PATIENTS
RHEUMATIC DISEASES
BIOLOGICAL MATERIALS
BLOOD CELLS
BODY FLUIDS
DISEASES
ELEMENTS
ENZYMES
KINETICS
MATERIALS
METALS
OXIDOREDUCTASES
REACTION KINETICS
SKELETAL DISEASES
TRANSITION ELEMENTS
560300* - Chemicals Metabolism & Toxicology