Design of molecular hosts, guests, and their complexes
Journal Article
·
· Science (Washington, D.C.); (United States)
The origins, definitions, tools, and guiding principles of host-guest chemistry are developed. Perching, nesting, and capsular complexes are exemplified through molecular model and crystal structure comparisons. The degree of preorganization of a host for binding is a central determinant of its binding power. Complementarity of binding site placement in host and guest is a central determinant of structural recognition in complexation. Examples are given of chiral recognition in complexation, of partial transacylase mimics, of caviplexes, and of a synthetic molecular cell. 54 references, 6 figures.
- Research Organization:
- Univ. of California, Los Angeles (USA)
- OSTI ID:
- 7005566
- Journal Information:
- Science (Washington, D.C.); (United States), Vol. 240
- Country of Publication:
- United States
- Language:
- English
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