Nickel absorption and kinetics in human volunteers

Technical Report · Sun Jan 01 00:00:00 EST 1989

OSTI ID:7005190

Sunderman, F W; Hopfer, S M; Sweeney, K R; Marcus, A H; Most, B M

Mathematical modeling was performed of the kinetics of nickel absorption, distribution and elimination in healthy human volunteers, who ingested NiSO4 in drinking water or added food. Nickel was analyzed by electrothermal atomic absorption spectrophotometry in serum, urine, and feces collected during 2 days before and 4 days after a specified NiSO4 dose (12 ug Ni/kg, N=4; 18 ug Ni/kg, N=4; or 50 ug Ni/kg, N=1). The study confirms that dietary constituents profoundly reduce the bioavailability of Ni2+ for alimentary absorption; approximately one-quarter of nickel ingested in drinking water after an over-night fast is absorbed from the human intestine and excreted in urine, compared to only one percent of nickel ingested in food. The compartmental model and kinetic parameters provided by the study will reduce the uncertainty of toxicological risk assessments of human exposures to nickel in drinking water and food.

• Research Organization: Connecticut Univ., Farmington, CT (USA). School of Medicine
• OSTI ID: 7005190
• Report Number(s): PB-90-198094/XAB
• Resource Relation: Other Information: Pub. in Proceedings of the Society for Experimental Biology and Medicine, Vol. 191, 5-11(Apr 1989)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
NICKEL
TOXICITY
ABSORPTION SPECTRA
BIOLOGICAL AVAILABILITY
BLOOD SERUM
ENVIRONMENTAL EXPOSURE PATHWAY
FECES
KIDNEYS
MAN
MATHEMATICAL MODELS
METABOLISM
URINE
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
ELEMENTS
MAMMALS
MATERIALS
METALS
ORGANS
PRIMATES
SPECTRA
TRANSITION ELEMENTS
VERTEBRATES
WASTES
560300* - Chemicals Metabolism & Toxicology