Reduced cadmium body burden in cadmium-exposed calves fed supplemental zinc
The objectives of this study were to evaluate the use of practical supplemental dietary zinc to modify the cadmium content in edible bovine tissues and to identify copper interactions with cadmium and zinc. The effect of supplemental zinc (200 or 600 ..mu..g/g) on the concentrations of cadmium, zinc, and copper in liver, kidney cortex, muscle, and blood of calves fed 50 ..mu..g/g cadmium for 60 days was evaluated. Blood samples were collected before and eight times after starting to feed cadmium or cadmium plus zinc. Liver, kidney, and muscle samples were collected when calves were slaughtered (baseline, at beginning of experimental feeding; cadmium-fed, at end of 60 days feeding). The cadmium concentrations of all sample types collected were markedly increased by the feeding of cadmium. Feeding 600 ..mu..g/g supplemental zinc significantly increased the zinc concentrations of liver, kidney cortex, and blood and decreased the cadmium accumulation in these organs as well as muscle. The copper concentrations of muscle or blood were not altered by feeding cadmium with or without zinc but those of liver and kidney cortex were significantly increased by higher dietary levels of zinc and cadmium. The potential use of dietary zinc salts in reducing cadmium body burden in food animals suspected or known to have high cadmium intakes is suggested.
- Research Organization:
- Ohio State Univ., Columbus
- OSTI ID:
- 7003158
- Journal Information:
- Environ. Res.; (United States), Vol. 33:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CADMIUM
BODY BURDEN
TISSUE DISTRIBUTION
COPPER
ZINC
BIOLOGICAL EFFECTS
CALVES
FEEDING
KIDNEYS
LIVER
MUSCLES
ANIMALS
BODY
CATTLE
DIGESTIVE SYSTEM
DISTRIBUTION
DOMESTIC ANIMALS
ELEMENTS
GLANDS
MAMMALS
METALS
ORGANS
RUMINANTS
TRANSITION ELEMENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)