Identification of a family of muscarinic acetylcholine receptor genes

Journal Article · Fri Jul 31 00:00:00 EDT 1987 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.3037705· OSTI ID:7000239

Bonner, T I; Buckley, N J; Young, A C; Brann, M R

Complementary DNAs for three different muscarinic acetylcholine receptors were isolated from a rat cerebral cortex library, and the cloned receptors were expressed in mammalian cells. Analysis of human and rat genomic clones indicates that there are at least four functional muscarinic receptor genes and that these genes lack introns in the coding sequence. This gene family provides a new basis for evaluating the diversity of muscarinic mechanisms in the nervous system.

• Research Organization: National Institute of Mental Health, Bethesda, MD (USA)
• OSTI ID: 7000239
• Journal Information: Science (Washington, D.C.); (United States), Vol. 237
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ACETYLCHOLINE
RECEPTORS
DNA SEQUENCING
DNA-CLONING
AMINO ACID SEQUENCE
MAN
NERVOUS SYSTEM
RATS
RECOMBINANT DNA
AMINES
AMMONIUM COMPOUNDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
CLONING
DNA
DRUGS
ESTERS
MAMMALS
MEMBRANE PROTEINS
MOLECULAR STRUCTURE
NEUROREGULATORS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PARASYMPATHOMIMETICS
PRIMATES
PROTEINS
QUATERNARY COMPOUNDS
RODENTS
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES
550200* - Biochemistry