Dopamine uptake sites in the striatum are distributed differentially in striosome and matrix compartments

Journal Article · Wed Nov 01 00:00:00 EST 1989 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.86.22.9020· OSTI ID:6999321

Graybiel, A M; Moratalla, R ^[1]

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1. Massachusetts Institute of Technology, Cambridge (USA)

A major mechanism of neurotransmitter inactivation at catecholaminergic synapses in reuptake of released transmitter at high-affinity uptake sites on presynaptic terminals. The authors have analyzed the anatomical distribution of site-selective ligand binding for dopamine uptake sites in the striatum of rat, cat, and monkey. The authors report here that desipramine-sensitive ({sup 3}H)mazindol binding sites have highly heterogeneous distributions in the dorsal and the ventral striatum. In the caudate nucleus of cat and monkey, ({sup 3}H)mazindol binding observes striosomal ordering, being reduced in striosomes and heightened in the extrastriosomal matrix. Some local heterogeneity appears in the ventral caudoputamen of the rat. Different subdivisions of the nucleus accumbens also have different binding levels. These findings suggest that some functional effects of psychoactive drugs, such as cocaine, and that bind to the dopamine-uptake complex could be related to the distribution of these specific uptake sites. The findings also raise the possibility that these distributions could result in selective neuronal vulnerability to neurotoxins, such as 1-methyl-4-phenylpyridine (MPP{sup +}), that depend on the dopamine-uptake complex for entry into neurons.

• OSTI ID: 6999321
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 86:22; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BRAIN
CYTOCHEMISTRY
DOPAMINE
UPTAKE
NEUROREGULATORS
TISSUE DISTRIBUTION
TRITIUM COMPOUNDS
CATS
INACTIVATION
MONKEYS
RATS
RECEPTORS
TOXINS
AMINES
ANIMALS
ANTIGENS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMISTRY
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CHEMISTRY
DISTRIBUTION
DRUGS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
MAMMALS
MATERIALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PRIMATES
PROTEINS
RODENTS
SYMPATHOMIMETICS
TOXIC MATERIALS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques