Macrodosimetry and microdosimetry in radioimmunotherapy
This progress report summarizes the research accomplished and its clinical implementation since July 15, 1989. To improve beta-particle dosimetry, a point-source function was developed that is valid for a wide range of beta-particle emitters. An analytical solution for beta-particle dose rates within and outside of slabs of finite thickness was validated in an experimental tumor system and is now being used in clinical radioimmunotherapy (RIT). Quantitative SPECT was validated in phantom studies, beagle dogs, and patients with Kaposi's sarcoma. It is currently being used in clinical RIT for patients with Hodgkin's disease or hepatoma. Additionally, methodologies and computer software are being developed for quantitative autoradiography to achieve absorbed-dose calculation on the cellular level. 7 refs., 1 tab.
- Research Organization:
- Johns Hopkins Oncology Center, Baltimore, MD (USA)
- Sponsoring Organization:
- DOE/ER
- DOE Contract Number:
- FG02-89ER60867
- OSTI ID:
- 6998879
- Report Number(s):
- DOE/ER/60867-1; ON: DE90007366; TRN: 90-008648
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DOSIMETRY
OPTIMIZATION
BETA PARTICLES
DOSE RATES
ANALYTICAL SOLUTION
RESEARCH PROGRAMS
IMPLEMENTATION
AUTORADIOGRAPHY
BEAGLES
CALCULATION METHODS
HEPATOMAS
HODGKINS DISEASE
INDIUM 111
INFORMATION DISSEMINATION
IODINE 131
LIVER
MAN
MICRODOSIMETRY
PHANTOMS
PROGRESS REPORT
RADIOIMMUNOTHERAPY
S CODES
SARCOMAS
YTTRIUM 90
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHARGED PARTICLES
COMPUTER CODES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
DOCUMENT TYPES
DOGS
DOSIMETRY
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
HOURS LIVING RADIOISOTOPES
IMMUNE SYSTEM DISEASES
IMMUNOLOGY
IMMUNOTHERAPY
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LYMPHOMAS
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
MOCKUP
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
PRIMATES
RADIOIMMUNOLOGY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
STRUCTURAL MODELS
THERAPY
VERTEBRATES
YTTRIUM ISOTOPES
655003* - Medical Physics- Dosimetry
560161 - Radionuclide Effects
Kinetics
& Toxicology- Man