Stage II endometrial carcinoma. Results and complications of a combined radiotherapeutic-surgical approach
Since one third of the patients with Stage II endometrial carcinoma have occult extrauterine pelvic metastases at diagnosis, adequate treatment must include the pelvic lymph nodes and parametria. Eighty-three patients with Stage II endometrial carcinoma were treated between January 1964 and December 1983. Sixty-nine patients (83%) received combined whole-pelvic irradiation and surgery, five (6%) had surgery alone and nine (11%) had radiotherapy alone. Five-year actuarial survival rates were 67%, 60%, and 38%, respectively. No pelvic recurrence occurred in the 69 patients who received the combined therapy, and there was no vaginal recurrence in the 80 patients treated with intracavity radium. There was a significantly lower incidence of pelvic lymph node metastases (P = 0.03) in patients treated with preoperative irradiation. The median time to recurrence was 17 months, with 67% of the recurrences diagnosed before 2 years, and 88% within 5 years. Ten patients (12%) incurred severe complications and three died as a result. Whole-pelvic irradiation, intracavity radium, and hysterectomy are effective treatment for occult pelvic and vaginal disease.
- Research Organization:
- Univ. of Texas M. D. Anderson Hospital and Tumor Institute, Houston (USA)
- OSTI ID:
- 6998493
- Journal Information:
- Cancer (Philadelphia); (United States), Vol. 61:8
- Country of Publication:
- United States
- Language:
- English
Similar Records
Evolution of radiotherapeutic techniques
Effects of irradiation of mixed muellerian tumors of the uterus. [Complications following external and internal radiotherapy and surgery]
Related Subjects
CARCINOMAS
RADIOTHERAPY
SURGERY
UTERUS
METASTASES
PATIENTS
RADIUM
SURVIVAL CURVES
ALKALINE EARTH METALS
BODY
DISEASES
ELEMENTS
FEMALE GENITALS
MEDICINE
METALS
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
550600 - Medicine