Iodide-induced thyrotoxicosis in a thyroidectomized patient with metastatic thyroid carcinoma

Journal Article · Fri Apr 15 00:00:00 EDT 1988 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19880415)61:8<1674::AID-CNCR2820610827>3.0.CO;2-E· OSTI ID:6997624

Yoshinari, M; Tokuyama, T; Okamura, K; Sato, K; Kusuda, K; Fujishima, M

An unusual case of iodide-induced thyrotoxicosis is documented in this article. The patient was a 64-year-old euthyroid man with acromegaly. He also had multiple follicular and papillary thyroid carcinomas with a metastatic lesion in the lumbar vertebrae. After a total thyroidectomy, he became slightly hypothyroid, and the lumbar lesion began to incorporate /sup 131/I by scintigraphy. When an iodine-containing contrast medium happened to be injected, a transient increase of serum thyroid hormone level was observed. After complete thyroid ablation with 83 mCi of /sup 131/I, the oral administration of 100 mg of potassium iodide for 7 days induced a prominent increase of serum thyroid hormone level. These findings indicated that the metastatic thyroid carcinoma could produce excess thyroid hormone insofar as a sufficient amount of iodide was given. Although this is the first report of such a case, iodide-induced thyrotoxicosis may not be rare in patients with thyroid carcinomas because the Wolff-Chaikoff effect is thought to be lost, and the organic iodinating activity and lysosomal protease activity are well-preserved.

• Research Organization: Kyushu Univ., Fukuoka City (Japan)
• OSTI ID: 6997624
• Journal Information: Cancer (Philadelphia); (United States), Vol. 61:8
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
IODINE 131
UPTAKE
THYROID
CARCINOMAS
THYROID HORMONES
BIOSYNTHESIS
ACROMEGALY
CONTRAST MEDIA
METASTASES
PATIENTS
SURGERY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MEDICINE
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PEPTIDE HORMONES
RADIOISOTOPES
SYNTHESIS
560161* - Radionuclide Effects
Kinetics
&amp; Toxicology- Man