Copper deficiency and tissue glutathione concentration in the rat

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-187-42634· OSTI ID:6993509

Allen, K G.D.; Arthur, J R; Morrice, P C; Nicol, F; Mills, C F

Copper deficiency in rats increased renal vein and arterial (heart) plasma GSH concentration by approximately 50%. There was no change in plasma GSSG concentration. Renal vein plasma GSSG/GSH ratio was decreased in copper deficiency, which is consistent with previous reports showing a copper-dependent thiol oxidase activity in the renal basement membrane. No change occurred in arterial plasma GSSG/GSH ratio. Hepatic GSH concentrations were also elevated by 50% in copper deficiency, GSSG concentrations were unaffected, but GSSG/GSH ratio was depressed. Renal and cardiac tissue GSH and GSSG were unaffected by copper deficiency. The decreased SOD activity and GSH-Px activity observed in copper deficiency may contribute to increased hepatic and plasma GSH concentrations.

• Research Organization: Rowett Research Institute, Aberdeen (England)
• OSTI ID: 6993509
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Vol. 187:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
COPPER
BIOLOGICAL EFFECTS
GLUTATHIONE
BIOCHEMICAL REACTION KINETICS
NUTRITIONAL DEFICIENCY
ANTIOXIDANTS
ENZYME ACTIVITY
RATS
ANIMALS
DRUGS
ELEMENTS
KINETICS
MAMMALS
METALS
ORGANIC COMPOUNDS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
RODENTS
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology