Surface heterogeneity of tumor cells and changes upon ionizing radiation
- Frederic Joliot-Curie National Research Institute for Radiobiology and Radiohygiene, Budapest (Hungary)
Heterogeneous distribution of surface domains is a characteristic feature of the tumor cell surface and the distribution differs from that of normal cells. During the malignant transformation the heterogeneity may change or disappear. Cell lines with various metastasizing capacities show different distributions of membrane domains or other differences in membrane or surface organization. We have demonstrated that the amount and distribution of negatively charged sites of B 16 melanoma membranes changed upon ionizing radiation (X-ray, {sup 60}Co-gamma). In the case of the P 388 lymphoma, however, only the amount of negatively charged sites change after irradiation, the distribution remains unaltered. Both features proved to be radioresistant in human lymphoid leukemic cells. 93 references.
- OSTI ID:
- 6992787
- Journal Information:
- Scanning Microscopy; (USA), Vol. 3:3; ISSN 0891-7035
- Country of Publication:
- United States
- Language:
- English
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COBALT 60
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EXPERIMENTAL NEOPLASMS
GAMMA RADIATION
LEUKEMIA
LYMPHOMAS
MAN
MELANOMAS
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ONCOGENIC TRANSFORMATIONS
REVIEWS
X RADIATION
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CELL CONSTITUENTS
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DISEASES
DOCUMENT TYPES
ELECTROMAGNETIC RADIATION
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEMBRANES
MICROSCOPY
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOT
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture