Low doses of urethane effectively inhibit spinal seizures evoked by sudden cooling of toad isolated spinal cord

Journal Article · Wed Jan 01 00:00:00 EST 1992 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(92)90022-H· OSTI ID:6992217

Pina-crespo, J C; Dalo, N L ^[1]

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1. Univ. Centroccidental Lisandro Alvarado, Barquisimeto (Venezuela)

The effect of low doses of urethane on three phases of spinal seizures evoked by sudden cooling (SSSC) of toad isolated spinal cord was studied. In control toads, SSSC began with a latency of 91[plus minus]3 sec exhibiting brief tremors, followed by clonic muscle contractions and finally reaching a tonic contraction. The latency of onset of seizures was significantly enhanced. The tonic phase was markedly abolished in toads pretreated intralymphaticaly with 0.15 g/kg of urethane. Tremors were the only phase observed in 55% of toads that received doses of 0.2 g/kg, and a total blockage of seizures was seen after doses of 0.25 g/kg of urethane in 50% of the preparations. A possible depressant effect of urethane on transmission mediated by excitatory amino acids is suggested.

• OSTI ID: 6992217
• Journal Information: Life Sciences; (United States), Vol. 51:7; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
SPINAL CORD
CONTRACTION
URETHANE
BIOLOGICAL EFFECTS
AMINO ACIDS
COOLING
FROGS
INHIBITION
AMPHIBIANS
ANIMALS
AQUATIC ORGANISMS
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology