Osteosarcoma risk after simultaneous incorporation of the long-lived radionuclide sup 227 Ac and the short-lived radionuclide sup 227 Th

Journal Article · Mon Jan 01 00:00:00 EST 1990 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577558· OSTI ID:6992109

Mueller, W A.M.; Murray, A B; Linzner, U; Luz, A ^[1]

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1. GSF-Institut fuer Pathologie, Neuherberg (Germany, F.R.)

The effect of injection of 1.85 kBq/kg of the long-lived radionuclide {sup 227}Ac on the induction of osteosarcomas in female NMRI mice by different dose levels (18.5, 74, and 185 kBq/kg) of the short-lived radionuclide {sup 227}Th was investigated. The highest absolute osteosarcoma incidence was observed with the highest doses of {sup 227}Th. Addition of {sup 227}Ac resulted in an additional osteosarcoma incidence only at the lowest dose of {sup 227}Th and did not affect the osteosarcoma incidence resulting from higher doses of {sup 227}Th. The longest times to tumor appearance were observed with {sup 227}Ac alone. The latent period in two different age groups (4 weeks and 10-12 weeks) appeared to be similar following injection with combined doses of {sup 227}Th and {sup 227}Ac but different after injection of each radionuclide alone.

• OSTI ID: 6992109
• Journal Information: Radiation Research; (USA), Vol. 121:1; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIUM 227
CARCINOGENESIS
OSTEOSARCOMAS
RADIOINDUCTION
THORIUM 227
ALPHA PARTICLES
BETA PARTICLES
MICE
RISK ASSESSMENT
SYNERGISM
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ACTINIUM ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
HEAVY NUCLEI
ISOTOPES
MAMMALS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
PATHOGENESIS
RADIOISOTOPES
RODENTS
SARCOMAS
SKELETAL DISEASES
THORIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells