Absorption and distribution of deuterium-labeled trans- and cis-11-octadecenoic acid in human plasma and lipoprotein lipids
Triglycerides of deuterium-labeled trans-11-, trans-11-cis-11- and cis-9-octadecenoic acid (11t-18:1-2H, 11c-18:1-2H) were simultaneously fed to two young adult male subjects. Plasma lipids from blood samples collected periodically for 48 hr were analyzed by gas chromatography-mass spectroscopy. The results indicate the delta 11-18:1-2H acids and 9c-18:1-2H were equally well absorbed; relative turnover rates were higher for the delta 11-18-1-2H acids in plasma triglycerides; incorporation of the delta 11-18:1-2H acids into plasma phosphatidylcholine was similar to 9c-18:1-2H, but distribution at the 1- and 2-acyl positions was substantially different; esterification of cholesterol with 11t-18:1 was extremely low; chain shortening of the delta 11-18:1-2H acids was 2-3 times greater than for 9c-18:1-2H; no evidence for desaturation or elongation of the 18:1-2H acids was detected; and a 40% isotopic dilution of the 18:1-2H acids in the chylomicron triglyceride fraction indicated the presence of a substantial intestinal triglyceride pool. Based on our present knowledge, these metabolic results for delta 11-18:1 acids present in hydrogenated oils and animal fats indicate that the delta 11 isomers are no more likely than 9c-18:1 to contribute to dietary fat-related health problems.
- Research Organization:
- Northern Regional Research Center, Peoria, IL
- OSTI ID:
- 6991329
- Journal Information:
- Lipids; (United States), Vol. 9
- Country of Publication:
- United States
- Language:
- English
Similar Records
Incorporation of deuterium-labeled trans- and cis-13-octadecenoic acids in human plasma lipids
Lipoprotein lipase activity and chylomicron clearance in rats fed a high fat diet
Related Subjects
DECANOIC ACID
METABOLISM
LIPOPROTEINS
TRIGLYCERIDES
CHOLESTEROL
DEUTERIUM COMPOUNDS
INTESTINAL ABSORPTION
PHOSPHOLIPIDS
TRACER TECHNIQUES
ABSORPTION
CARBOXYLIC ACIDS
ESTERS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LIPIDS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PROTEINS
STEROIDS
STEROLS
UPTAKE
550501* - Metabolism- Tracer Techniques