Multiple toxic doses of methamphetamine alter neurotensin concentrations in various region of the rat brain

Hanson, G R; Merchant, K; Gibb, J W; Letter, A A

Title: Multiple toxic doses of methamphetamine alter neurotensin concentrations in various region of the rat brain

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Abstract

The authors have previously reported that multiple high doses of methamphetamine (METH) alter neuronal monoamine metabolism and release. Recently, Hokfelt et al. showed that neurotensin, a tridecapeptide, has neurotransmitter properties which may be involved with DA neuronal activity. In the present study they investigated the possible effects of METH on the CNS neurotensin system. Five doses of METH (15 mg/kg) were administered every 6 h; control and treated rats were sacrificed 18 h after the last dose and concentrations of neurotensin-like immuno-reactivity (NTLI) were measured by radioimmunoassay. NTLI was elevated 200-300% in the nucleus accumbens, neostriatum, and substantia nigra; 30-40% increases in NTLI were measured in the hippocampus and hypothalamus. No change was observed in amygdala, A-10 or periaqueductal gray. In contrast to the above measured areas, the frontal lobe and olfactory bulb showed decreases of 25-35%. These findings demonstrate that METH treatment alters the activities of several CNS neurotensin systems, possibly due to the influence of this drug on DA pathways. The variability in the type and magnitude of these responses suggests that DA and neurotensin systems interact by more than one mechanism.

Authors:: Hanson, G R; Merchant, K; Gibb, J W; Letter, A A

Publication Date:: Wed Mar 05 00:00:00 EST 1986

Research Org.:: Univ. of Utah, Salt Lake City

OSTI Identifier:: 6989221

Report Number(s):: CONF-8604222-
Journal ID: CODEN: FEPRA

Resource Type:: Conference

Journal Name:: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

Additional Journal Information:: Journal Volume: 45:4; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; AMINES; METABOLISM; AMPHETAMINES; BIOLOGICAL EFFECTS; BRAIN; IMMUNE REACTIONS; NERVES; RADIOIMMUNOASSAY; RATS; ANALEPTICS; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENTS; BODY; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM AGENTS; DRUGS; IMMUNOASSAY; IMMUNOLOGY; ISOTOPE APPLICATIONS; MAMMALS; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANS; RADIOASSAY; RADIOIMMUNOLOGY; RODENTS; SYMPATHOMIMETICS; TRACER TECHNIQUES; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology; 550201 - Biochemistry- Tracer Techniques

Citation Formats


                    Hanson, G R, Merchant, K, Gibb, J W, and Letter, A A. Multiple toxic doses of methamphetamine alter neurotensin concentrations in various region of the rat brain.  United States: N. p., 1986. 
        Web.

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                    Hanson, G R, Merchant, K, Gibb, J W, & Letter, A A. Multiple toxic doses of methamphetamine alter neurotensin concentrations in various region of the rat brain.  United States.

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                    Hanson, G R, Merchant, K, Gibb, J W, and Letter, A A. 1986.  
        "Multiple toxic doses of methamphetamine alter neurotensin concentrations in various region of the rat brain".  United States.

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@article{osti_6989221,

  title        = {Multiple toxic doses of methamphetamine alter neurotensin concentrations in various region of the rat brain},

  author       = {Hanson, G R and Merchant, K and Gibb, J W and Letter, A A},

  abstractNote = {The authors have previously reported that multiple high doses of methamphetamine (METH) alter neuronal monoamine metabolism and release. Recently, Hokfelt et al. showed that neurotensin, a tridecapeptide, has neurotransmitter properties which may be involved with DA neuronal activity. In the present study they investigated the possible effects of METH on the CNS neurotensin system. Five doses of METH (15 mg/kg) were administered every 6 h; control and treated rats were sacrificed 18 h after the last dose and concentrations of neurotensin-like immuno-reactivity (NTLI) were measured by radioimmunoassay. NTLI was elevated 200-300% in the nucleus accumbens, neostriatum, and substantia nigra; 30-40% increases in NTLI were measured in the hippocampus and hypothalamus. No change was observed in amygdala, A-10 or periaqueductal gray. In contrast to the above measured areas, the frontal lobe and olfactory bulb showed decreases of 25-35%. These findings demonstrate that METH treatment alters the activities of several CNS neurotensin systems, possibly due to the influence of this drug on DA pathways. The variability in the type and magnitude of these responses suggests that DA and neurotensin systems interact by more than one mechanism.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/6989221},
  journal      = {Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)},
number       = ,

  volume       = 45:4,

  place        = {United States},

  year         = {Wed Mar 05 00:00:00 EST 1986},

  month        = {Wed Mar 05 00:00:00 EST 1986}

}

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