Effect of plasmapheresis on the liver uptake of ApoB-lipoproteins labeled with technetium-99m

Journal Article · Fri Dec 01 00:00:00 EST 1989 · Artificial Organs (New York); (USA)

DOI:https://doi.org/10.1111/j.1525-1594.1989.tb01571.x· OSTI ID:6983788

Anisimova, O Ju; Konovalov, G A; Agapov, I I; Fuki, I V; Sergienko, V B; Repin, V S; Kukharchuk, V V ^[1]

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1. USSR Cardiology Research Center, Moscow (USSR)

To study liver low density lipoprotein (LDL)-receptor activity before and after plasmapheresis, ({sup 99m}Tc) very low density lipoprotein (VLDL) was used. Autologous VLDL was labeled, sterilized by filtration, and administered intravenously to patients under a gamma camera. The uptake of lipoproteins in the liver was measured by scintiscanning. Liver activity curves were generated for each patient. The liver activity in patients with the heterozygous form of familial hypercholesterolemia (FH) and in patients with symptomatic atherosclerosis (SA) without hereditary deficit of LDL receptors was reduced as compared to healthy people. Plasmapheresis enhanced the liver uptake of the {sup 99m}Tc-labeled lipoproteins in atherosclerotic patients. Thus, labeled metabolites could presumably be of use in assessing the effect of plasmapheresis on liver function.

• OSTI ID: 6983788
• Journal Information: Artificial Organs (New York); (USA), Vol. 13:6; ISSN 0160-564X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
APOLIPOPROTEINS
UPTAKE
LIVER
SCINTISCANNING
ARTERIOSCLEROSIS
BLOOD PLASMA
DYNAMIC FUNCTION STUDIES
GAMMA CAMERAS
ISOMERIC NUCLEI
PATIENTS
RECEPTORS
TECHNETIUM 99
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CAMERAS
CARDIOVASCULAR DISEASES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIPIDS
LIPOPROTEINS
MATERIALS
MEMBRANE PROTEINS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
VASCULAR DISEASES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics