Ordering of metal-ion toxicities in different species--extrapolation to man

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Health Physics; (USA)

DOI:https://doi.org/10.1097/00004032-198907001-00014· OSTI ID:6983224

England, M W; Turner, J E; Hingerty, B E; Jacobson, K B ^[1]

---

1. Oak Ridge National Lab., TN (USA)

Our previous attempts to predict the toxicities of 24 metal ions for a given species, using physicochemical parameters associated with the ions, are summarized. In our current attempt we have chosen indicators of toxicity for biological systems of increasing levels of complexity--starting with individual biological molecules and ascending to mice as representative of higher-order animals. The numerical values for these indicators have been normalized to a scale of 100 for Mg{sup 2+} (essentially nontoxic) and 0 for Cd{sup 2+} (very toxic). To give predicted toxicities to humans, extrapolations across biological species have been made for each of the metal ions considered. The predicted values are then compared with threshold limit values (TLV) from the literature. Both methods for predicting toxicities have their advantages and disadvantages, and both have limited success for metal ions. However, the second approach suggests that the TLV for Cu{sup 2+} should be lower than that currently recommended.

• OSTI ID: 6983224
• Journal Information: Health Physics; (USA), Journal Name: Health Physics; (USA); ISSN 0017-9078
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
METALS
TOXICITY
BIOLOGICAL MODELS
CADMIUM
COPPER
DROSOPHILA
MAGNESIUM
MAXIMUM PERMISSIBLE EXPOSURE
MICE
ALKALINE EARTH METALS
ANIMALS
ARTHROPODS
DIPTERA
ELEMENTS
FLIES
FRUIT FLIES
INSECTS
INVERTEBRATES
MAMMALS
RODENTS
SAFETY STANDARDS
STANDARDS
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology