Advanced carcinoma of the stomach treated with definitive proton therapy

Journal Article · Sun Apr 01 00:00:00 EST 1990 · American Journal of Gastroenterology; (USA)

OSTI ID:6975600

Koyama, S; Kawanishi, N; Fukutomi, H; Osuga, T; Iijima, T; Tsujii, H; Kitagawa, T ^[1]

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1. Univ. of Tsukuba (Japan)

We report the case of a 72-yr-old man who suffered from severe chronic emphysema with poor pulmonary function, and who had advanced cancer of the stomach. Proton beam radiotherapy was applied to the lesion, since surgery was contraindicated. The total dose to the stomach lesion was 61 Gy in 7 wk. The tumor on the stomach regressed, with flattening of the round wall of the lesion. The reactive changes of the proton beam radiotherapy, based on the histopathological examination, revealed extensive tumor necrosis and sparing of vital architecture of normal tissue around the irradiated tumor tissue. Only small clusters of vital or devitalized tumor cells with less than approximately 5% of the whole tumor tissue remained after treatment. We suggest that a high dose of radiation delivered by well-defined proton field could result in an improved therapeutic outcome without undue risk of injury to normal tissue.

• OSTI ID: 6975600
• Journal Information: American Journal of Gastroenterology; (USA), Vol. 85:4; ISSN 0002-9270
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
RADIOTHERAPY
PROTON BEAMS
STOMACH
RADIATION DOSES
BEAMS
BODY
DIGESTIVE SYSTEM
DISEASES
DOSES
GASTROINTESTINAL TRACT
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEON BEAMS
ORGANS
PARTICLE BEAMS
RADIOLOGY
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)