Choriocarcinoma: blocking factor and monoclonal antibody iodine 131 imaging
Postoperative iodine 131 monoclonal antibody localization in metastatic choriocarcinoma was accomplished in this study. The monoclonal antibody was prepared to male choriocarcinoma which cross reacted with gestational choriocarcinoma. The antibody was raised against whole choriocarcinoma cells and human chorionic gonadotropin (hCG) cross reactivity was excluded. The purified antibody was iodinated with /sup 131/I and successfully imaged BeWo choriocarcinoma transplanted in nude mice; however, imaging of choriocarcinoma in a patient was verified only after resection. It is our belief that failure to sufficiently concentrate the antibody in the tumor before operation was due to blocking factor in the serum of the patient. Blocking factor and hCG dropped postoperatively. Blocking factor activity in 15 patients with metastatic trophoblastic disease was monitored and, like hCG, was found to be a sensitive indicator of the presence of disease. Its efficacy may be in the small number of patients without hCG but with persistent disease.
- Research Organization:
- Department of Gynecology and Obstetrics, Medical College of Wisconsin, Milwaukee
- OSTI ID:
- 6974914
- Journal Information:
- Am. J. Obstet. Gynecol.; (United States), Vol. 148:7
- Country of Publication:
- United States
- Language:
- English
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IODINE 131
DIAGNOSTIC USES
MONOCLONAL ANTIBODIES
CARCINOMAS
DIAGNOSIS
METASTASES
PATIENTS
RADIOISOTOPE SCANNING
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DISEASES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPES
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics