Quantitative evaluation of fatty liver by computed tomography in rabbits

Journal Article · Sun Apr 01 00:00:00 EST 1984 · Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.142.4.741· OSTI ID:6973843

Kawata, R; Sakata, K; Kunieda, T; Saji, S; Doi, H; Nozawa, Y

Biochemical, histologic, and computed tomographic (CT) examinations of the liver were performed in 32 rabbits in which fatty liver was induced by prolonged intravenous fat infusion. In two groups of rabbits, in which 2 and 4 g/kg/day of fat emulsion was administered, respectively, posttreatment reduction in CT value of mild degree was observed. In the group that received 8 g/kg/day of fat emulsion, posttreatment change in CT value was sufficient for a diagnosis of fatty liver of moderate degree. Reduction in CT value in fatty liver might be due largely to accumulation of triglyceride and cholesterol in the liver cells. Significant correlation was found between changes in CT value of the liver and degrees of histological fat accumulation in the liver cells. Consecutive measurement of CT values of the liver during prolonged intravenous hyperalimentation is a nonagressive method of diagnosing fatty liver.

• Research Organization: Gifu Univ. School of Medicine, Japan
• OSTI ID: 6973843
• Journal Information: Am. J. Roentgenol.; (United States), Vol. 142:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
ADIPOSE TISSUE
BIOLOGICAL ACCUMULATION
DIGESTIVE SYSTEM DISEASES
DIAGNOSIS
LIVER
COMPUTERIZED TOMOGRAPHY
BIOCHEMISTRY
RABBITS
ANIMAL TISSUES
ANIMALS
BODY
CHEMISTRY
CONNECTIVE TISSUE
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
GLANDS
MAMMALS
ORGANS
TISSUES
TOMOGRAPHY
VERTEBRATES
550602* - Medicine- External Radiation in Diagnostics- (1980-)
550200 - Biochemistry
550900 - Pathology