Variability of the thymidine labeling index in squamous cell carcinoma of the head and neck

Journal Article · Wed Jun 01 00:00:00 EDT 1988 · Laryngoscope; (United States)

DOI:https://doi.org/10.1288/00005537-198806000-00018· OSTI ID:6971781

Greenberg, B; Woo, L; Blatchford, S; Aguirre, M; Garewal, H

Tritiated thymidine (/sup 3/HTdR) labeling is the standard technique for determining the kinetic activity of tumors. This method has been used to label multiple sections of tumor specimens obtained from seven patients with advanced squamous cell carcinoma of the head and neck. Considerable variability was observed in the labeling index in different sites from the same specimen. To reduce the large sampling error due to heterogeneity, we recommend that an average value be determined from multiple sections when employing this technique.

• Research Organization: Univ. of Connecticut Health Center, Farmington (USA)
• OSTI ID: 6971781
• Journal Information: Laryngoscope; (United States), Vol. 98
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CARCINOMAS
DIAGNOSIS
HEAD
NECK
NUCLEAR MEDICINE
LABELLING
CELL DIVISION
ERRORS
PATIENTS
QUALITY CONTROL
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AZINES
BODY
BODY AREAS
CONTROL
DISEASES
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MEDICINE
NEOPLASMS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RIBOSIDES
550901* - Pathology- Tracer Techniques