Effect of pure zinc deficiency on glucose tolerance and insulin and glucagon levels
Abstract
The effect of zinc deficiency on glucose tolerance was investigated using intragastric force-feeding to obviate decreased food intake and altered eating patterns. Three groups of weanling male Sprague-Dawley rats were fed a purified powdered zinc-deficient diet: zinc-deficient ad libitum fed animals (ZDA); zinc-replete gavage force-fed controls (ZRF) fed the zinc-deficient diet in water with zinc (25 ppm); zinc-deficient gavage force-fed animals (ZDF) fed the zinc-deficient diet in distilled water. A fourth group of zinc-supplemented rats fed the diet ad libitum was included to determine caloric intake for ZDF and ZRF gavage fed groups. After 8 days of feeding, the zinc concentration in the serum and pancreas were lower in both zinc-deficient groups, but the difference was much greater in the ZDF rats than in the ZDA. The ZDF group had impaired glucose tolerance curves, yet blood insulin and glucagon levels were normal. The ZDA group had normal glucose tolerance with low insulin levels compared to the ZRF group. The islet cell morphology among the three dietary groups were similar. These results suggest that the glucose intolerance observed in ZDF rats is not due to altered blood insulin and glucagon levels but rather to peripheral resistance to insulin action.
- Authors:
- Publication Date:
- Research Org.:
- Univ. of Nebraska Medical Center, Omaha
- OSTI Identifier:
- 6962408
- Report Number(s):
- CONF-8604222-
Journal ID: CODEN: FEPRA; TRN: 87-006132
- Resource Type:
- Conference
- Journal Name:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
- Additional Journal Information:
- Journal Volume: 45:4; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; GLUCOSE; TOLERANCE; ZINC; BIOLOGICAL EFFECTS; NUTRITIONAL DEFICIENCY; BLOOD PLASMA; GLUCAGON; INSULIN; METABOLISM; RATS; ALDEHYDES; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BODY FLUIDS; CARBOHYDRATES; ELEMENTS; HEXOSES; HORMONES; MAMMALS; MATERIALS; METALS; MONOSACCHARIDES; ORGANIC COMPOUNDS; PEPTIDE HORMONES; PEPTIDES; POLYPEPTIDES; PROTEINS; RODENTS; SACCHARIDES; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology
Citation Formats
Park, J H.Y., Grandjean, C J, Hart, M H, Erdman, S H, Pour, P, and Vanderhoof, J A. Effect of pure zinc deficiency on glucose tolerance and insulin and glucagon levels. United States: N. p., 1986.
Web.
Park, J H.Y., Grandjean, C J, Hart, M H, Erdman, S H, Pour, P, & Vanderhoof, J A. Effect of pure zinc deficiency on glucose tolerance and insulin and glucagon levels. United States.
Park, J H.Y., Grandjean, C J, Hart, M H, Erdman, S H, Pour, P, and Vanderhoof, J A. 1986.
"Effect of pure zinc deficiency on glucose tolerance and insulin and glucagon levels". United States.
@article{osti_6962408,
title = {Effect of pure zinc deficiency on glucose tolerance and insulin and glucagon levels},
author = {Park, J H.Y. and Grandjean, C J and Hart, M H and Erdman, S H and Pour, P and Vanderhoof, J A},
abstractNote = {The effect of zinc deficiency on glucose tolerance was investigated using intragastric force-feeding to obviate decreased food intake and altered eating patterns. Three groups of weanling male Sprague-Dawley rats were fed a purified powdered zinc-deficient diet: zinc-deficient ad libitum fed animals (ZDA); zinc-replete gavage force-fed controls (ZRF) fed the zinc-deficient diet in water with zinc (25 ppm); zinc-deficient gavage force-fed animals (ZDF) fed the zinc-deficient diet in distilled water. A fourth group of zinc-supplemented rats fed the diet ad libitum was included to determine caloric intake for ZDF and ZRF gavage fed groups. After 8 days of feeding, the zinc concentration in the serum and pancreas were lower in both zinc-deficient groups, but the difference was much greater in the ZDF rats than in the ZDA. The ZDF group had impaired glucose tolerance curves, yet blood insulin and glucagon levels were normal. The ZDA group had normal glucose tolerance with low insulin levels compared to the ZRF group. The islet cell morphology among the three dietary groups were similar. These results suggest that the glucose intolerance observed in ZDF rats is not due to altered blood insulin and glucagon levels but rather to peripheral resistance to insulin action.},
doi = {},
url = {https://www.osti.gov/biblio/6962408},
journal = {Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)},
number = ,
volume = 45:4,
place = {United States},
year = {Wed Mar 05 00:00:00 EST 1986},
month = {Wed Mar 05 00:00:00 EST 1986}
}