Effect of benzene and lead on relationship between. delta. -aminolevulinic acid and brain myelin proteins
The aim of this investigation was to study binding of ALA by brain myelin under normal conditions and under the influence of lead and benzene. Rabbits of three different groups were given an intercranial injection of /sup 14/C-ALA (50 microCi) in physiological saline in a volume of 0.25 ml. The myelin fraction was obtained by differential centrifugation and the /sup 14/C-ALA in it was assayed on an LKB liquid scintillation counter. By determining the quantity of exogenous /sup 14/C-ALA bound with myelin, the authors found that myelin of white matter in the brain contains more of the acid than myelin of the gray matter. Data on binding of /sup 14/C-ALA calculated per milligram of each group of myelin proteins isolated is given.
- Research Organization:
- Institute of Experimental and Clinical Medicine, Tallin
- OSTI ID:
- 6958387
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 100:10
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZENE
BIOLOGICAL EFFECTS
BRAIN
RADIORECEPTOR ASSAY
LEAD
LEVULINIC ACID
RETENTION
RABBITS
AMINO ACIDS
CARBON 14 COMPOUNDS
MYELIN
SCINTISCANNING
ANIMALS
AROMATICS
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
ELEMENTS
HYDROCARBONS
ISOTOPE APPLICATIONS
KETO ACIDS
LABELLED COMPOUNDS
MAMMALS
MEMBRANES
METALS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
TRACER TECHNIQUES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques
560300 - Chemicals Metabolism & Toxicology