Comparative mapping of the Grpr locus on the X chromosomes of man and mouse
Journal Article
·
· Genomics; (United States)
- MRC Radiobiology Unit, Oxfordshire (United Kingdom)
The gastrin-releasing peptide receptor has been previously cloned from both humans and mice. The authors have mapped the mouse gastrin-releasing peptide receptor (Grpr) locus using a polymorphic CA[sub n] repeat located in the 5[prime] untranslated region of the gene and a Mus spretus/Mus musculus interspecific backcross. The Grpr locus mapped between the Pdha-1 and Amg loci on the mouse X chromosome. Studies in man indicate that GRPR maps to the Xp21.2-p22.3 region of the human X chromosome and not to the Xp11-q11 interval as previously reported. The assignment of the GRPR locus to the distal Xp region is supported by the comparative map position in the mouse. 25 refs., 3 figs.
- OSTI ID:
- 6955747
- Journal Information:
- Genomics; (United States), Vol. 17:1; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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