Effects of hydroxymethanesulfonate on airway function in subjects with asthma. Final report

Technical Report · Fri Jun 30 00:00:00 EDT 1989

OSTI ID:6946946

Sheppard, D; Balmes, J R; Aris, R M; Christian, D

The organic ion hydroxymethanesulfonate (HMSA) has been measured in micro-molecular concentrations in acidic fogs in southern California. HMSA is a stable adduct in fogs with a pH range of 3-5, but it is likely to dissociate at pH 6.6, the pH of the human airways fluid lining. It was hypothesized that HMSA may have a specific bronchoconstrictor effect because HMSA may dissociate in the airway lumen generating SO{sub 2} and CH{sub 2}O, both of which have bronchoconstrictor potential. In order to determine whether HMSA has such an effect, a total of 19 subjects with mild to moderate asthma were studied in an exposure chamber in which freely breathing and exercising subjects inhaled simulated fogs containing HMSA at a concentration (1000 micro M) higher than the ambient levels for 1 hour. The results indicated no significant bronchoconstrictor effect for acute exposures of HMSA.

• Research Organization: California Univ., San Francisco, CA (USA). Lung Biology Center
• OSTI ID: 6946946
• Report Number(s): PB-90-164542/XAB
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CALIFORNIA
AIR POLLUTION
ORGANIC SULFUR COMPOUNDS
BIOLOGICAL EFFECTS
ACID RAIN
ASTHMA
EXPOSURE CHAMBERS
FOG
INHALATION
LUNGS
MAN
PH VALUE
PROGRESS REPORT
SIMULATION
ANIMALS
ATMOSPHERIC PRECIPITATIONS
BODY
DISEASES
DOCUMENT TYPES
FEDERAL REGION IX
INTAKE
MAMMALS
NORTH AMERICA
ORGANIC COMPOUNDS
ORGANS
POLLUTION
PRIMATES
RAIN
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
USA
VERTEBRATES
540120* - Environment
Atmospheric- Chemicals Monitoring & Transport- (1990-)
560300 - Chemicals Metabolism & Toxicology