The iron chelator desferrioxamine attenuates postischemic ventricular dysfunction

Journal Article · Tue Dec 01 00:00:00 EST 1987 · American Journal of Physiology; (USA)

OSTI ID:6945534

Bolli, R; Patel, B S; Zhu, Weixi; O'Neill, P G; Hartley, C J; Charlat, M L; Roberts, R ^[1]

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1. Baylor College of Medicine, Houston, TX (US)

Recent evidence suggests that postischemic myocardial dysfunction (stunning) may be mediated by oxygen free radicals, but the mechanism by which they produce myocellular damage remains unknown. Since iron catalyzes formation of hydroxyl radicals (HO{center dot}) as well as HO{center dot}-initiated lipid peroxidation, the authors explored the potential role of this metal in the pathogenesis of myocardial stunning. Open-chest dogs undergoing a 15-min occlusion of the left anterior descending coronary artery (LAD) followed by 4 h of reperfusion (REP) received the iron chelator desferrioxamine intravenously or normal saline. Regional myocardial function was assessed by measuring systolic wall thickening with an epicardial Doppler probe. The two groups exhibited comparable systolic thickening under base-line conditions and similar degrees of dyskinesis during ischemia. After REP, however, recovery of contractile function as considerably greater in desferrioxamine-treated compared with control dogs. These differences could not be ascribed to hemodynamic factors. The results suggest that iron-catalyzed reactions (possibly HO{center dot} generation) play a significant role in myocardial stunning after a brief episode of reversible regional ischemia.

• OSTI ID: 6945534
• Journal Information: American Journal of Physiology; (USA), Vol. 253:6; ISSN 0002-9513
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BLOOD FLOW
DYNAMIC FUNCTION STUDIES
DEFEROXAMINE
BIOLOGICAL EFFECTS
MYOCARDIAL INFARCTION
PATHOGENESIS
BIOCHEMISTRY
DOGS
DOPPLER EFFECT
HYDROXYL RADICALS
IRON COMPOUNDS
NIOBIUM 95
STRONTIUM 85
ALKALINE EARTH ISOTOPES
AMINES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARDIOVASCULAR DISEASES
CHELATING AGENTS
CHEMISTRY
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NIOBIUM ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
RADICALS
RADIOISOTOPES
STRONTIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques