Alterations in glucose kinetics induced by pentobarbital anesthesia
- Louisiana State Univ. Medical Center, New Orleans (USA)
Because pentobarbital is often used in investigations related to carbohydrate metabolism, the in vivo effect of this drug on glucose homeostasis was studied. Glucose kinetics assessed by the constant intravenous infusion of (6-{sup 3}H)- and (U-{sup 14}C)glucose, were determined in three groups of catheterized fasted rats: conscious, anesthetized and body temperature maintained, and anesthetized but body temperature not maintained. After induction of anesthesia, marked hypothermia developed in rats not provided with external heat. Anesthetized rats that developed hypothermia showed a decrease in mean arterial blood pressure (25%) and heart rate (40%). Likewise, the plasma lactate concentration and the rates of glucose appearance, recycling, and metabolic clearance were reduced by 30-50% in the hypothermic anesthetized rats. Changes in whole-body carbohydrate metabolism were prevented when body temperature was maintained. Because plasma pentobarbital levels were similar between the euthermic and hypothermic rats during the first 2 h of the experiment, the rapid reduction in glucose metabolism in this latter group appears related to the decrease in body temperature. The continuous infusion of epinephrine produced alterations in glucose kinetics that were not different between conscious animals and anesthetized rats with body temperature maintained. Thus pentobarbital-anesthetized rats became hypothermic when kept at room temperature and exhibited marked decreases in glucose metabolism. Such changes were absent when body temperature was maintained during anesthesia.
- OSTI ID:
- 6945441
- Journal Information:
- American Journal of Physiology; (USA), Vol. 253:6; ISSN 0002-9513
- Country of Publication:
- United States
- Language:
- English
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ANESTHESIA
PHYSIOLOGY
GLUCOSE
BIOCHEMICAL REACTION KINETICS
LABELLED COMPOUNDS
METABOLISM
PHENOBARBITAL
BIOLOGICAL EFFECTS
ADRENALINE
CARBON 14 COMPOUNDS
FASTING
LACTIC ACID
RATS
TRITIUM COMPOUNDS
ADRENAL HORMONES
ALDEHYDES
ANESTHETICS
ANIMALS
ANTICONVULSANTS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZINES
BARBITURATES
CARBOHYDRATES
CARBOXYLIC ACIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
HETEROCYCLIC COMPOUNDS
HEXOSES
HYDROGEN COMPOUNDS
HYDROXY ACIDS
HYPNOTICS AND SEDATIVES
KINETICS
MAMMALS
MONOSACCHARIDES
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PYRIMIDINES
REACTION KINETICS
RODENTS
SACCHARIDES
SYMPATHOMIMETICS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques