Interaction of DNA with indolylalkylamine radioprotective compounds

Journal Article · Tue Jul 01 00:00:00 EDT 1986 · Pharmaceut. Chem. J.; (United States)

OSTI ID:6942294

Vainberg, Yu P; Pinevich, S V; Shagalov, L B

In the creation of radioprotective preparations, the problem of decreasing the toxicity is critical. Within the scope of this problem, the authors began to study the possibility of modifying the biological properties of the radioprotectant compounds serotonin and 4,5-benztryptamine by means of their complex formation with DNA. The authors examine the degree of relationship between effects in irradiated mice and the ability of serotonin, 4,5-, 6-7-, and 5,6-benztryptamines to interact with DNA. The interaction of a given compound with DNA and the strength of the complex which is formed were also evaluated.

• Research Organization: Institute of Biophysics, Ministry of Public Health of the USSR, Moscow
• OSTI ID: 6942294
• Journal Information: Pharmaceut. Chem. J.; (United States), Vol. 19:9
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DNA
BIOSYNTHESIS
COMPLEXOMETRY
MICE
BIOLOGICAL RADIATION EFFECTS
RADIOPROTECTIVE SUBSTANCES
BIOCHEMISTRY
COMPLEXES
EXTERNAL IRRADIATION
METABOLISM
RADIOSENSITIVITY EFFECTS
SEROTONIN
TOXICITY
TRYPTAMINES
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOLOGICAL EFFECTS
CHEMISTRY
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
IRRADIATION
MAMMALS
NEUROREGULATORS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRROLES
RADIATION EFFECTS
RODENTS
SYMPATHOMIMETICS
SYNTHESIS
VERTEBRATES
550501* - Metabolism- Tracer Techniques